Factors influencing diagnostic accuracy

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Main PageDiagnostic accuracyFactors influencing diagnostic accuracy
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There is overwhelming evidence confirming, that dermoscopy improves the diagnostic accuracy for melanoma in comparison to inspection with unaided eye.

Type of algorithm used to evaluate the lesions

  • Pattern analysis[1]
  • ABCD rule[2]
  • Seven point checklist[3]
  • Menzies and associates algorithm[4]

A number of diagnostic algorithms have been developed for the dermoscopic evaluation of pigmented lesions. Pattern analysis has been shown to have a higher specificity than the other algorithms, but no significant differences were found with regard to sensitivity.[5]

  1. Pehamberger et al.: In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J. Am. Acad. Dermatol. 1987;17:571-83. PMID: 3668002.
  2. Nachbar et al.: The ABCD rule of dermatoscopy. High prospective value in the diagnosis of doubtful melanocytic skin lesions. J. Am. Acad. Dermatol. 1994;30:551-9. PMID: 8157780.
  3. Argenziano et al.: Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. Arch Dermatol 1998;134:1563-70. PMID: 9875194.
  4. Menzies et al.: Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. Arch Dermatol 1996;132:1178-82. PMID: 8859028.
  5. Kittler et al.: Diagnostic accuracy of dermoscopy. Lancet Oncol. 2002;3:159-65. PMID: 11902502.
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