Juvenile xanthogranuloma

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 Authored by: Shamir Geller     ·  Ashfaq A. Marghoob

 Keywords:   juvenile xanthogranuloma · general medicine · histiocytosis
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Author(s) Shamir Geller · Ashfaq A. Marghoob
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Status update November 23, 2017
Status by Ralph P. Braun
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Erythematous border encircling an orange-yellow area with white linear streakslines radial

Juvenile xanthogranuloma

Juvenile xanthogranuloma is the most common non-Langerhans cell histiocytosis and it has a characteristic dermoscopic pattern that has been described as a ‘setting sun’. It appears as an orange-yellow area encircled by erythremic border.[1] Other dermoscopic features include pale yellow globulesThis glossary term has not yet been described., subtle pigment networkGrid-like pattern consisting of interconnecting pigmented lines surrounding hypopigmented holes., whitish streaks, and branched linear or dotted vesselstiny pinpoint vessels flat melanocytic lesions inflammatory diseases Bowen disease.

The dermoscopic features were suggested to correlate with the maturation level of the lesions. The ’setting sun’ appearance was found in early evolutionary and in fully developed lesions. In fully developed lesions, the surrounding erythema decreased and yellow globules became more evident. In late regressive lesions, prominent whitish streaks were identified.[2]

DermoscopyDermoscopy is a non invasive diagnostic method. is helpful in differentiating juvenile xanthogranuloma from other conditions that present as solitary yellow-orange lesions.
  1. Palmer et al.: Dermoscopic appearance of juvenile xanthogranuloma. Dermatology 2007;215:256-259. PMID: 17823526. DOI.
  2. Song et al.: Structural correlations between dermoscopic and histopathological features of juvenile xanthogranuloma. J Eur Acad Dermatol Venereol 2011;25:259-263. PMID: 20698915. DOI.