|Description||This chapter describes the histopathological correlation of negative networkSerpiginous interconnecting broadened hypopigmented lines that surround elongated and curvilinear globules. in dermoscopyThe examination of [skin lesions] with a 'dermatoscope'. This traditionally consists of a magnifier (typically x10), a non-polarised light source, a transparent plate and a liquid medium between the instrument and the skin, and allows inspection of skin lesions unobstructed by skin surface reflections. Modern dermatoscopes dispense with the use of liquid medium and instead use polarised light to cancel out skin surface reflections.|
|Author(s)||Oriol Yélamos · Katrin Kerl · Ralph P. Braun|
|Responsible author||Ralph Braun → send e-mail|
|Status update||July 2, 2019|
|Status by||Ralph P. Braun|
Negative networkSerpiginous interconnecting broadened hypopigmented lines that surround elongated and curvilinear globules. (formerly also known as inverse networkThis glossary term has not yet been described.) consists of serpiginous lighter grid lines that connect between hyperpigmentedThis glossary term has not yet been described., elongated-to-curvilinear globules (Pizzichetta et al., 2014). Histologically, the negative network seems to correlate to thin elongated and hypopigmented rete ridgesEpidermal extensions that project into the underlying dermis bridging and surrounding large melanocyticThis glossary term has not yet been described. nests within a widened dermal papillae (Marghoob and Braun, 2012). The negative network is highly specific for melanomaThis glossary term has not yet been described., especially for melanomas arising in a nevus (Shitara et al., 2015), although it can also be seen in Spitz neviThis glossary term has not yet been described. and rarely in congenital neviis a type of melanocytic nevus (or mole) found in infants at birth. This type of birthmark occurs in an estimated 1% of infants worldwide; it is located in the area of the head and neck 15% of the time. (Pizzichetta et al., 2014).