(3 votes)
Description This chapter describes the histopathological correlation of negative network in dermoscopy
Author(s) Oriol Yélamos · Katrin Kerl · Ralph P. Braun
Responsible author Ralph Braun→ send e-mail
Status unknown
Status update July 2, 2019
Status by Ralph P. Braun

Negative network (formerly also known as inverse network) consists of serpiginous lighter grid lines that connect between hyperpigmented, elongated-to-curvilinear globules (Pizzichetta et al., 2014). Histologically, the negative network seems to correlate to thin elongated and hypopigmented rete ridges bridging and surrounding large melanocytic nests within a widened dermal papillae (Marghoob and Braun, 2012). The negative network is highly specific for melanoma, especially for melanomas arising in a nevus (Shitara et al., 2015), although it can also be seen in Spitz nevi and rarely in congenital nevi (Pizzichetta et al., 2014).

Negative network schematic 32.jpg
Negative network small.JPG

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