Negative network

From dermoscopedia

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Description This chapter describes the histopathological correlation of negative network in dermoscopy
Author(s) Oriol Yélamos · Katrin Kerl · Ralph P. Braun
Responsible author Ralph Braun→ send e-mail
Status unknown
Status update July 2, 2019
Status by Ralph P. Braun


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Negative network (formerly also known as inverse network) consists of serpiginous lighter grid lines that connect between hyperpigmented, elongated-to-curvilinear globules (Pizzichetta et al., 2014). Histologically, the negative network seems to correlate to thin elongated and hypopigmented rete ridges bridging and surrounding large melanocytic nests within a widened dermal papillae (Marghoob and Braun, 2012). The negative network is highly specific for melanoma, especially for melanomas arising in a nevus (Shitara et al., 2015), although it can also be seen in Spitz nevi and rarely in congenital nevi (Pizzichetta et al., 2014).

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