Differences between histologic and dermoscopic criteria

From dermoscopedia

Main PageHistopathologic correlation of dermoscopic structuresDifferences between histologic and dermoscopic criteria
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 Authored by: Ralph P. Braun     ·  Katrin Kerl

 Keywords:   pathology · dermatopathology · histology · dermoscopy · melanoma
Description In this chapter we describe the difference between histologic and dermoscopyDermoscopy is a non invasive diagnostic method. criteriameasure of how well one variable or set of variables predicts an outcome
Author(s) Ralph P. Braun · Katrin Kerl
Owner Ralph Braun→ send e-mail
Status released
Status update December 8, 2017
Status by Ralph P. Braun


Histopathologic evaluation is performed on vertical sections of tissue, allowing the assessment of the full depth of the lesion from scanning magnification to a cellular-level magnification.

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HistopathologyThis glossary term has not yet been described. is performed on paraffin-embedded tissue, allowing for special stains and immunohistochemical techniques that may assist in diagnosisis the identification of the nature and cause of a certain phenomenon. Diagnosis is used in many different disciplines with variations in the use of logic, analytics, and experience to determine "cause and effect". In systems engineering and computer science, it is typically used to determine the causes of symptoms, mitigations, and solutions. Dermoscopic evaluation is based on a horizontal view of the entire lesion.
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Another advantage of dermoscopy examination is that the clinician can examine the other lesions of the patient and that he or she can integrate the findings in the context of the patient.
Dermoscopic structuresThis glossary term has not yet been described. and colors are two-dimensional surface projections of tissue structures (e.g., melanocyticThis glossary term has not yet been described. nests and blood vesselsare the part of the circulatory system, and microcirculation, that transports blood throughout the human body). The dermoscopist sees the entire in the horizontal plane. The inspection of the skin by the dermoscopist is generally limited in depth to the papillary dermis. Another important limitation is that, dermoscopy does not allow the evaluation of the lesion at a cellular level.
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In addition the dermatopathologist has access to special stains which provide additional information (MelanA, S100, HMB45 etc.)

An important advantage is dermoscopy allows the follow up of lesions. This provides important information regarding the lesion’s biology and dynamic. With dermoscopy, we can identify “colors” and “structures” that are not perceived by the unaided eye.