From dermoscopedia

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 Editor: Ralph P. Braun

 Author(s): Ralph P. Braun     ·  Katrin Kerl
Description In this chapter we describe the term globules and its histopathological correlation
Author(s) Ralph P. Braun · Katrin Kerl
Responsible author Ralph Braun→ send e-mail
Status unknown
Status update May 27, 2017
Status by Ralph P. Braun

Regular Globules

Irregular Globules

Globular pattern schematic.jpg
Globules are symmetrical, round to oval, well-demarcated structuresThis glossary term has not yet been described. with a diameter that is larger than 0.1 mm. They usually correspond to nests of pigmented benignis any condition that is harmless in the long run or malignant melanocytes situated in the lower epidermis, at the DEJ, or in the papillary dermis. On occasion globules may correspond to large clumps of melanin, melanophages, or pigmented milia cysts. Like dotsDots are small, round structures of less than 0.1 mm in diameter that have a red color when corresponding to blood vessels; however, when due to melanin, their color ranges from black, brown, to blue-gray depending on the depth and concentration of the melanin in the skin (Tyndall effect)., the color of globules may be brown, black, blue-gray, or red. The significance of these colorsThis glossary term has not yet been described. is the same as was discussed for dots above. Both dots and globules may occur in neviThis glossary term has not yet been described. as well as in melanomaThis glossary term has not yet been described.. In nevi, the globules are uniform in size, shape, and color (mostly brown), and evenly distributed in the lesion, being mostly present at its center surrounded by a networkThis glossary term has not yet been described., or circumferentially along the entire perimeter of the nevusThis glossary term has not yet been described., or uniformly distributed throughout the nevus. Dots in nevi are usually brown in color and overlie the pigment network linesstreaksThis glossary term has not yet been described.. In contrast, in melanomas, globules and dots vary in size, shape, and colorColor (American English) or colour (Commonwealth English) is the characteristic of human visual perception described through color categories, with names such as red, yellow, purple, or blue., are unevenly distributed in the lesion, and are frequently found focally at the periphery of lesions. Because both dots and globules frequently correlate with nests of melanocytes, they are often described for simplicity and reproducibility as a combined term “dotSee [[Glossary:Dots|Dots]]’s and globulesThis glossary term has not yet been described.”.

Globules histology.jpg