Colors in skin lesions can provide important morphologic information: Melanin is the most important chromophore in pigmented skin lesions. Depending on the anatomic location and concentration of melanin in the skinThis glossary term has not yet been described., the colors perceived on dermoscopy range from black to blue (i.e., Tyndall effect). If melanin is located in the stratum corneum or immediately beneath it, the lesion would appear black on dermoscopy. Melanin at the dermoepidermal junction (DEJ) would be perceived as light brown to dark brown, depending on its density. Melanin in the dermis results in shades of blue to gray. Thus, the colors seen on dermoscopy allow the clinician to predict the anatomic location of the cells that contain melanin (e.g., melanocytes, keratinocytes, and melanophages). Other important determinants of lesion colorColor (American English) or colour (Commonwealth English) is the characteristic of human visual perception described through color categories, with names such as red, yellow, purple, or blue. include hemoglobin in red blood cells (pink to red colors) and collagen fi bers in the dermis (white color).