Hypopigmented structureless areas

From dermoscopedia

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 Editor: Ralph P. Braun

 Author(s): Ralph P. Braun     ·  Katrin Kerl     ·  Oriol Yélamos
Description This chapter describes the dermoscopyThe examination of [skin lesions] with a 'dermatoscope'. This traditionally consists of a magnifier (typically x10), a non-polarised light source, a transparent plate and a liquid medium between the instrument and the skin, and allows inspection of skin lesions unobstructed by skin surface reflections. Modern dermatoscopes dispense with the use of liquid medium and instead use polarised light to cancel out skin surface reflections. term hypopigmented structureless areas and its histopathological correlation
Author(s) Ralph P. Braun · Katrin Kerl · Oriol Yélamos
Responsible author Ralph Braun→ send e-mail
Status released
Status update July 2, 2019
Status by Ralph P. Braun


Hypopigmented structureless areas have a lighter pigment compared with the rest of the lesion; however, they manifest the same or slightly more pigment compared with the surrounding normal skin (N.B.: structureless areas that are hyperpigmented are called blotches). Focal structureless areas within a lesion are a common finding in neviThis glossary term has not yet been described..

Nevus central hypopigmentation.jpg
In contrast, focal tan to light brown structureless areas at the periphery of a melanocyticThis glossary term has not yet been described. lesion is commonly associated with melanomaThis glossary term has not yet been described.. Peripherally located structureless areas in melanoma tend to have a light brown to fawn color and tend to end abruptly at the edge of a lesion. Histologically, these areas are characterized by flattening of the DEJ (loss of the undulating pattern of rete ridgesEpidermal extensions that project into the underlying dermis and dermal papillae) and scattering of atypical melanocytes in suprabasal epidermal layers (i.e., pagetoid cells).

Melanoma displaying tan structuresless area

ReferencesThis is material contained in a footnote or bibliography holding further information.