Areas within a lesion that are devoid of any network or other structures, such as globules or regressionThis glossary term has not yet been described. structures, are called “structureless areas.” Structureless areas are defined as areas with a size that is at least 10% of the lesion’s surface area and are devoid of any discernible structures, such as globulesThis glossary term has not yet been described., network, or regression structures (i.e., scars, pepperingdots gray, granularityThis glossary term has not yet been described., or blue-white veil over fl at areas).
Structureless areas hypopigmentedThey are hypopigmented compared with the rest of the lesion; however, they manifest the same or slightly more pigment compared with the surrounding normal skin (N.B.: structureless areas that are hyperpigmented are called blotches). Focal structureless areas within a lesion are a common finding in neviThis glossary term has not yet been described.. However, focal tan to light brown structureless areas at the periphery of a melanocyticThis glossary term has not yet been described. lesion is commonly associated with melanomaThis glossary term has not yet been described.. Peripherally located structureless areas in melanoma tend to have a light brown to fawn colorColor (American English) or colour (Commonwealth English) is the characteristic of human visual perception described through color categories, with names such as red, yellow, purple, or blue. and tend to end abruptly at the edge of a lesion. Histologically, these areas are characterized by flattening of the DEJ (loss of the undulating pattern of rete ridges and dermal papillae) and scattering of atypical melanocytes in suprabasal epidermal layers (i.e., pagetoid cells).
Structureless areas, hyperpigmented (Blotches)A blotchDark structureless areas is defined as an area with a size that is at least 10% of the lesion’s surface area and is heavily pigmentedThis glossary term has not yet been described.. In a blotch the melanin pigment is often present throughout the skinThis glossary term has not yet been described., including the stratum corneum, epidermis, and the dermis. The dark pigment in a blotch visually obscures the ability to discern any underlying structures. Blotches can be regular or irregular.
Regular hyperpigmented structureless areablotch If centric hypermelanotic Clark (“dysplastic”) nevus if eccentric melanoma (BlotchDark structureless areas)
Regular blotches are defined as those that display symmetry, regular borders,homogenous dark hue, and are located within the center of the lesion. A pigment network often surrounds a regular blotchOne blotch within center of lesion and surrounded by network. Regular blotches are associated with nevi.
Regular blotches can be seen in “activated” nevi. This structure is due to heavy concentrations of melanin in the stratum corneum. Because the pigment is present in the stratum corneum, it can easily be stripped off using a tape-stripping procedure, thereby revealing underlying structures.